Mutagenesis of the crystal contact of acidic fibroblast growth factor
نویسندگان
چکیده
منابع مشابه
Mutagenesis of the crystal contact of acidic fibroblast growth factor
An attempt has been made to improve a crystal contact of human acidic fibroblast growth factor (haFGF; 140 amino acids) to control the crystal growth, because haFGF crystallizes only as a thin-plate form, yielding crystals suitable for X-ray but not neutron diffraction. X-ray crystal analysis of haFGF showed that the Glu81 side chain, located at a crystal contact between haFGF molecules, is in ...
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Compared to basic fibroblast growth factor (bFGF), a widely distributed, broad spectrum mitogen and mesoderm inducer, acidic fibroblast growth factor (aFGF) is reported to have an essentially neural distribution and to be undetectable in the early embryo. In the present investigation, we used immunoblotting and immunochemistry to assess the cellular and tissue distributions of aFGF and bFGF in ...
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ژورنال
عنوان ژورنال: Journal of Synchrotron Radiation
سال: 2008
ISSN: 0909-0495
DOI: 10.1107/s0909049508004470